CD276 Protein (CD276) (Fc Tag)

Catalog No. ABIN7320967

Recombinant CD276 protein expressed in Human Cells.

Quick Overview for CD276 Protein (CD276) (Fc Tag) (ABIN7320967)

Target: CD276

Protein Type: Recombinant

Origin: Cynomolgus

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This CD276 protein is labelled with Fc Tag.

Purpose: Recombinant Cynomolgus B7-H3/CD276 Protein (Fc Tag)

Sequence: Leu29-Glu465

Characteristics: Recombinant Cynomolgus CD276 Molecule is produced by our Mammalian expression system and the target gene encoding Leu29-Glu465 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD276

Alternative Name: B7-H3/CD276

Background:

Background: CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20-27 % amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.

Synonym: CD276 antigen, CD276, B7 homolog 3, B7-H3,CD276

Molecular Weight: 74 kDa

NCBI Accession: XP_015308534

Pathways: Cancer Immune Checkpoints