CD276 Protein (CD276) (Fc Tag)

Catalog No. ABIN7321099

This Recombinant CD276 protein is produced in HEK-293 Cells.

Quick Overview for CD276 Protein (CD276) (Fc Tag) (ABIN7321099)

Target: CD276

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purity: > 85 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This CD276 protein is labelled with Fc Tag.

Purpose: Recombinant Rat B7-H3/CD276 Protein (Fc Tag)

Sequence: Met1-Phe244

Characteristics: A DNA sequence encoding the rat CD276 (Q7TPB4) (Met1-Phe244) was expressed with the Fc region of human IgG1 at the C-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD276

Alternative Name: B7-H3/CD276

Background:

Background: B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.Immune CheckpointImmune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: CD276;B7h3

Molecular Weight: 50.6 kDa

UniProt: Q7TPB4

Pathways: Cancer Immune Checkpoints