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Contactin 1 Protein (CNTN1) (His tag)

CNTN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Catalog No. ABIN7195254
  • Target See all Contactin 1 (CNTN1) Proteins
    Contactin 1 (CNTN1)
    Protein Type
    Recombinant
    Origin
    • 4
    • 3
    • 2
    Mouse
    Source
    • 6
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Contactin 1 protein is labelled with His tag.
    Purpose
    Recombinant Mouse Contactin 1/CNTN1 Protein (His Tag)
    Sequence
    Met1-Leu1000
    Characteristics
    A DNA sequence encoding the mouse CNTN1 (NP_031753.1) (Met1-Leu1000) was expressed with a C-terminal polyhistidine tag.
    Purity
    > 90 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Contactin 1 (CNTN1)
    Alternative Name
    Contactin 1/CNTN1 (CNTN1 Products)
    Synonyms
    F3 Protein, GP135 Protein, AW495098 Protein, CNTN Protein, F3cam Protein, F3/F11 Protein, cntn-A Protein, F11 Protein, CNTN1 Protein, cntn1 Protein, contactin 1 Protein, contactin 1 L homeolog Protein, contactin 1a Protein, CNTN1 Protein, Cntn1 Protein, cntn1.L Protein, cntn1a Protein
    Background

    Background: Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na+ channels in neurons.

    Synonym: AW495098,CNTN,F3cam,usl

    Molecular Weight
    110.5 kDa
    NCBI Accession
    NP_031753
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