DEFB4A Protein (AA 24-64)

Catalog No. ABIN7319217

Recombinant DEFB4A protein expressed in Escherichia coli (E. coli).

Quick Overview for DEFB4A Protein (AA 24-64) (ABIN7319217)

Target: DEFB4A (DEFB4) (Defensin, beta 4A (DEFB4))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 24-64

Purpose: Recombinant Human β-Defensin 4A/DEFB4A Protein

Sequence: Gly24-Pro64

Characteristics: Recombinant Human beta-Defensin 4A is produced by our E.coli expression system and the target gene encoding Gly24-Pro64 is expressed.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: DEFB4A (DEFB4) (Defensin, beta 4A (DEFB4))

Alternative Name: beta-Defensin 4A/DEFB4A

Background: BD-2,Beta 2,Beta-Defensin 2,Beta-Defensin 4A,DEFB102,DEFB2,DEFB4,DEFB4A,DEFB4B,Defensin,SAP1,Skin-Antimicrobial Peptide 1,hBD-2,β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38 % and 33 % amino acid sequence identity with mouse and rat BD3, respectively.

Molecular Weight:

Calculated MW: 4.3 kDa

Observed MW: 9 kDa

Gene ID: 100289462

UniProt: O15263