DPP7 Protein (His tag)

Catalog No. ABIN7195431

This Recombinant DPP7 protein is produced in HEK-293 Cells.

Quick Overview for DPP7 Protein (His tag) (ABIN7195431)

Target: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 98 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This DPP7 protein is labelled with His tag.

Purpose: Recombinant Human DPP7/DPPII/DPP2 Protein (His Tag)

Sequence: Met 1-Leu 492

Characteristics: A DNA sequence encoding the human DPPII (NP_037511.2) (Met 1-Leu 492) with a C-terminal polyhistidine tag was expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Alternative Name: DPP7/DPPII/DPP2

Background:

Background: DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.

Synonym: DPP2,DPPII,QPP

Molecular Weight: 53.6 kDa

NCBI Accession: NP_037511