DPP7 Protein (His tag)

Catalog No. ABIN7195432

Product Details

Target: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This DPP7 protein is labelled with His tag.

Purpose: Recombinant Mouse DPP7/DPPII/DPP2 Protein (His Tag)(Active)

Sequence: Met1-Arg 506

Characteristics: A DNA sequence encoding the mouse DPP7 (Q9ET221) (Met1-Arg 506) was expressed, with a C-terminal polyhistidine tag.

Purity: > 92 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave the fluorogenic peptide substrate, Lys-Pro-AMC(KP-AMC).The specific activity is > 20,000 pmoles/min/μg.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Alternative Name: DPP7/DPPII/DPP2 (DPP7 Products)

Synonyms: DPP2 Protein, DPPII Protein, QPP Protein, Dpp2 Protein, wu:fb19g02 Protein, zgc:112274 Protein, zgc:113564 Protein, DPP7 Protein, MGC151556 Protein, dipeptidyl peptidase 7 Protein, dipeptidylpeptidase 7 Protein, dipeptidyl-peptidase 7 Protein, DPP7 Protein, Dpp7 Protein, Shewana3_0712 Protein, Kkor_1052 Protein, Riean_0388 Protein, dpp7 Protein, Isop_1372 Protein

Background:

Background: DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.

Synonym: Dpp2,DPPII,QPP

Molecular Weight: 53.7 kDa