DUSP14 Protein (His-MBP)
Quick Overview for DUSP14 Protein (His-MBP) (ABIN7317376)
Target
See all DUSP14 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This DUSP14 protein is labelled with His-MBP.
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Purpose
- Recombinant Human DUSP14/MKP-6 Protein (His & MBP Tag)
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Sequence
- Met 1 -His 191
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Characteristics
- A DNA sequence encoding the human DUSP14 (O95147) (Met 1 -His 191) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198) protein (His tag)
custom-made DUSP14 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198) protein (His tag)custom-made DUSP14 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198) protein (GST tag)DUSP14 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP, PAA
Dual Specificity Phosphatase 14 (DUSP14) protein (Myc-DYKDDDDK Tag)DUSP14 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Dual Specificity Phosphatase 14 (DUSP14) (AA 1-198), (full length) protein (His-SUMO Tag)DUSP14 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))
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Alternative Name
- DUSP14/MKP-6
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Background
- MKP-L,MKP6,Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (MAPK) / extracellular signal-regulated kinase 1 / 2 (ERK 1 / 2) pathway. DUSP14 phosphatase activity has been confirmed to be inhibited by PTP inhibitor IV. PTP inhibitor binds to the catalytic site of DUSP14. PTP inhibitor IV effectively and specifically inhibited DUSP14-mediated dephosphorylation of JNK, a member of the mitogen-activated protein kinase (MAPK) family through dephosphorylation of both the Ser / Thr and Tyr residues of MAPKs.
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Molecular Weight
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Calculated MW: 65.0 kDa
Observed MW: 60 kDa
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Gene ID
- 11072
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UniProt
- O95147
Target
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