FCGR1 Protein (His tag)

Catalog No. ABIN7320521

This Recombinant FCGR1 protein is produced in Human Cells.

Quick Overview for FCGR1 Protein (His tag) (ABIN7320521)

Target: FCGR1 (Fc Receptor, IgG, High Affinity I (FCGR1))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This FCGR1 protein is labelled with His tag.

Purpose: Recombinant Mouse CD64/FCGR1 Protein (His Tag)

Sequence: Glu25-Pro297

Characteristics: Recombinant Mouse High affinity immunoglobulin gamma Fc receptor I is produced by our Mammalian expression system and the target gene encoding Glu25-Pro297 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FCGR1 (Fc Receptor, IgG, High Affinity I (FCGR1))

Alternative Name: CD64/FCGR1

Background:

Background: CD64, also known as Fc-gamma receptor 1 (FcγRI), is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-type used to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. It is normally expressed on the surfaces of monocytes and macrophages.

Synonym: High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, CD64,FcgammaRI,IGGHAFC

Molecular Weight: 31.5 kDa

UniProt: P26151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process