Fibrillin 1 Protein (FBN1) (His tag)

Catalog No. ABIN7319692

This Recombinant Fibrillin 1 protein is produced in Human Cells.

Quick Overview for Fibrillin 1 Protein (FBN1) (His tag) (ABIN7319692)

Target: Fibrillin 1 (FBN1)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Fibrillin 1 protein is labelled with His tag.

Purpose: Recombinant Human Fibrillin-1/FBN1 Protein (His Tag)

Sequence: Ser2732-His287

Characteristics: Recombinant Human Fibrillin-1 is produced by our Mammalian expression system and the target gene encoding Ser2732-His2871 is expressed with a 8His tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Fibrillin 1 (FBN1)

Alternative Name: Fibrillin-1/FBN1

Background:

Background: Asprosin is a protein hormone that is produced by white adipose tissue in mammals (and potentially by other tissues), which is then transported to the liver and stimulates it to release glucose into the blood stream. In the liver asprosin activates rapid glucose release by a cAMP-dependent pathway. The glucose release by the liver into the blood stream is vital for brain function and survival during fasting. People with neonatal progeroid syndrome lack asprosin, while people with insulin resistance have it in abundance. In animal tests asprosin showed potential for treating type 2 diabetes. When antibodies targeting asprosin were injected into diabetic mice, blood glucose and insulin levels improved.

Synonym: Fibrillin-1, FBN1, Asprosin, FBN

Molecular Weight: 17 kDa

UniProt: P35555

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome