FGF4 Protein

Catalog No. ABIN7320894

This Recombinant FGF4 protein is produced in Escherichia coli (E. coli).

Quick Overview for FGF4 Protein (ABIN7320894)

Target: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Mouse Fibroblast Growth Factor 4/FGF-4

Sequence: Ser67--Leu202

Characteristics: Recombinant Mouse Fibroblast Growth Factor 4 is produced by our E.coli expression system and the target gene encoding Ser67-Leu202 is expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Alternative Name: Fibroblast Growth Factor 4/FGF-4

Background:

Background: Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91 % , 82 %, 94 % and 91 % aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.

Synonym: Fibroblast growth factor 4, FGF-4, Heparin secretory-transforming protein 1, HST, HST-1, HSTF-1, Heparin-binding growth factor 4, HBGF-4, Transforming protein KS3, FGF4, HST, HSTF1, KS3 

Molecular Weight: 15.2 kDa

UniProt: P11403

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance