FH Protein

Catalog No. ABIN7318507

This Recombinant FH protein is expressed in Escherichia coli (E. coli).

Quick Overview for FH Protein (ABIN7318507)

Target: FH (Fumarate Hydratase (FH))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human Fumarase/FH Protein

Sequence: Ala45-Lys510

Characteristics: Recombinant Human Fumarase is produced by our E.coli expression system and the target gene encoding Ala45-Lys510 is expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: FH (Fumarate Hydratase (FH))

Alternative Name: Fumarase/FH

Background:

Background: Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.

Synonym: Fumarate Hydratase Mitochondrial, Fumarase, FH,FMRD,HLRCC,LRCC,MCL,MCUL1

Molecular Weight: 50.2 kDa

UniProt: P07954