GCDH Protein (His tag)

Catalog No. ABIN7318540

This Recombinant GCDH protein is expressed in Escherichia coli (E. coli).

Quick Overview for GCDH Protein (His tag) (ABIN7318540)

Target: GCDH (Glutaryl-CoA Dehydrogenase (GCDH))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This GCDH protein is labelled with His tag.

Purpose: Recombinant Human GCDH Protein (His Tag)

Sequence: Arg45-Lys438

Characteristics: Recombinant Human Glutaryl-CoA Dehydrogenase, Mitochondrial is produced by our E.coli expression system and the target gene encoding Arg45-Lys438 is expressed with a 6His tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, pH 7.4.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: GCDH (Glutaryl-CoA Dehydrogenase (GCDH))

Alternative Name: GCDH

Background:

Background: Glutaryl-CoA Dehydrogenase Mitochondrial (GCDH) is an enzyme that acts upon glutaryl-coenzyme A, creating crotonyl-coenzyme A. It plays a role in the metabolism of lysine, hydroxylysine and tryptophan. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive Glutaryl-CoA and electron-transfer flavoprotein to (E)-but-2-enoyl-CoA, CO2 and reduced electron-transfer flavoprotein. A defect in this enzyme is associated with neurological condition glutaric acidemia type 1 and cause a progressive form of early-onset generalized dystonia.

Synonym: Glutaryl-CoA Dehydrogenase Mitochondrial, GCD, GCDH

Molecular Weight: 45.0 kDa

UniProt: Q92947