GDF11 Protein (AA 299-407)

Catalog No. ABIN7318551

Recombinant GDF11 protein expressed in HEK-293 Cells.

Quick Overview for GDF11 Protein (AA 299-407) (ABIN7318551)

Target: GDF11 (Growth Differentiation Factor 11 (GDF11))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 299-407

Purpose: Recombinant Human GDF11/BMP-11 Protein

Sequence: Asn299-Ser407

Characteristics: Recombinant Human Growth differentiation factor 11 is produced by our Mammalian expression system and the target gene encoding Asn299-Ser407 is expressed.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 50 % glycerol, pH 7.4.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: GDF11 (Growth Differentiation Factor 11 (GDF11))

Alternative Name: GDF11/BMP-11

Background: BMP-11,Bone morphogenetic protein 11,GDF-11,Growth/differentiation factor 11,Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.

Molecular Weight:

Calculated MW: 12.5 kDa

Observed MW: 13-20 kDa

Gene ID: 10220

UniProt: O95390