GAMT Protein (His tag)
Quick Overview for GAMT Protein (His tag) (ABIN7318555)
Target
See all GAMT ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This GAMT protein is labelled with His tag.
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Purpose
- Recombinant Human GAMT Protein (His Tag)
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Sequence
- Met 1-Gly236
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Characteristics
- Recombinant Human Guanidinoacetate N-methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Guanidinoacetate N-Methyltransferase (GAMT) (AA 1-236) protein (His tag)
GAMT Origin: Rat Host: Yeast Recombinant > 90 % ELISA
Guanidinoacetate N-Methyltransferase (GAMT) (AA 1-236), (full length) protein (His tag)GAMT Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
Guanidinoacetate N-Methyltransferase (GAMT) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GAMT Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 1 mM DTT, pH 8.0.
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Preservative
- Dithiothreitol (DTT)
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Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- GAMT (Guanidinoacetate N-Methyltransferase (GAMT))
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Alternative Name
- GAMT
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Background
- GAMT,Guanidinoacetate N-methyltransferase,PIG2,TP53I2,GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.
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Molecular Weight
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Calculated MW: 29.5 kDa
Observed MW: 27-32 kDa
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Gene ID
- 2593
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UniProt
- Q14353
Target
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