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HMOX1 Protein

HMOX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7318568
  • Target See all HMOX1 Proteins
    HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
    Protein Type
    Recombinant
    Origin
    • 13
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    Human
    Source
    • 16
    • 6
    • 3
    • 2
    • 2
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human HO-1/HMOX1 Protein
    Sequence
    Met 1-Thr 261
    Characteristics
    Recombinant Human Heme Oxygenase 1 is produced by our E.coli expression system and the target gene encoding Met1-Thr261 is expressed.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product HMOX1 Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
    Alternative Name
    HO-1/HMOX1 (HMOX1 Products)
    Background

    Background: Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.

    Synonym: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1

    Molecular Weight
    29.9 kDa
    UniProt
    P09601
    Pathways
    Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome
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