HIST2H2BE Protein

Catalog No. ABIN7317573

Product Details

Target: HIST2H2BE (Histone H2B Type 2-E (HIST2H2BE))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human Histone cluster 2 H2BE/HIST2H2BE Protein

Sequence: Met 1-Lys 126

Characteristics: A DNA sequence encoding the human HIST2H2BE (Q16778) (Met 1-Lys 126) was expressed and purified.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 2 mM β-Mercaptoethanol, pH 6.9

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: HIST2H2BE (Histone H2B Type 2-E (HIST2H2BE))

Alternative Name: Histone cluster 2 H2BE/HIST2H2BE (HIST2H2BE Products)

Synonyms: RGD1562346 Protein, AV127319 Protein, H2b-613 Protein, T25626 Protein, DKFZp469C0528 Protein, H2b Protein, GL105 Protein, H2B Protein, H2B.1 Protein, H2BFQ Protein, H2BGL105 Protein, H2BQ Protein, histone cluster 2 H2B family member E Protein, histone cluster 2, H2be Protein, histone cluster 1, H2bl Protein, histone cluster 2 H2B family member e Protein, histone H2B Protein, Hist2h2be Protein, HIST2H2BE Protein, Hist1h2bl Protein, H2B Protein

Background:

Background: Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and 2. subtype diversity in a class(H1, H2A, H2B, H3 or H4) within a species. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machineries that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. However, extracellular histones are a double-edged sword because they also damage host tissue and may cause death. Histones bound to platelets, induced calcium influx, and recruited plasma adhesion proteins such as fibrinogen to induce platelet aggregation. Histone H2B proteins have been studied in a variety of species and is easily detecred in most species. The reversible ubiquitylation of histone H2B has long been implicated in transcriptional activation and gene silencing. Phosphorylation of H2B serine 32 occurs in normal cycling and mitogen-stimulated cells. Notably, this phosphorylation is elevated in skin cancer cell lines and tissues compared with normal counterparts. HIST2H2BE is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Synonym: GL105,H2B,H2B.1,H2BFQ,H2BGL105,H2BQ,MGC119802,MGC119804,MGC129733,MGC129734

Molecular Weight: 14.2 kDa

UniProt: Q16778