HOXA1 Protein (His tag)

Catalog No. ABIN7317346

This Recombinant HOXA1 protein is produced in Escherichia coli (E. coli).

Quick Overview for HOXA1 Protein (His tag) (ABIN7317346)

Target: HOXA1 (Homeobox A1 (HOXA1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 85 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This HOXA1 protein is labelled with His tag.

Purpose: Recombinant Human HOXA1 Protein (His Tag)

Sequence: Met 1-His 335

Characteristics: A DNA sequence encoding the mature form of human HOXA1 isoform 3 (P49639-1) (Met 1-His 335) was expressed, with a polyhistide tag at the N-terminus.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 30 % glycerol, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: HOXA1 (Homeobox A1 (HOXA1))

Alternative Name: HOXA1

Background:

Background: Homeobox protein Hox-A1 is a transcription factor encoded by HOXA1 gene. This gene is one of the four types of homeobox genes each of which contains a homobox DNA sequence that codes for the homeodomain, a region of 60 amino acids responsible for the DNA binding exhibited by these homeobox proteins. These Homeobox genes are essential metazoan genes as they determine the identity of embryonic regions along the anterio-posterior axis. The homeobox protein Hox-A1 may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Early in its development, the vertebrate hindbrain is transiently subdivided into a series of compartments called rhombomeres. Genes have been identified whose expression patterns distinguish these cellular compartments. Two of these genes, Hoxa1 and Hoxa2, have been shown to be required for proper patterning of the early mouse hindbrain and the associated neural crest. It has been detected HOXA1 expression in a variety of human breast cancer lesions, suggesting that HOXA1 may be required for the establishment of breast cancer cells phenotype. 

Synonym: BSAS;HOX1;HOX1F

Molecular Weight: 38 kDa

Pathways: Sensory Perception of Sound