IgG1 Fc/IGHG1 protein (Fc Tag)

Catalog No. ABIN7320546

Recombinant IgG1 Fc/IGHG1 protein expressed in Human Cells.

Quick Overview for IgG1 Fc/IGHG1 protein (Fc Tag) (ABIN7320546)

Target: IgG1 Fc/IGHG1

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: Fc Tag

Purpose: Recombinant Mouse IgG1 Fc/IGHG1 Protein

Sequence: Pro99-Lys324

Characteristics: Recombinant Mouse Immunoglobulin G1 Fc is produced by our Mammalian expression system and the target gene encoding Pro99-Lys324 is expressed.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IgG1 Fc/IGHG1

Background:

Background: As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity.

Synonym: g gamma-1 chain C region,IGHG1

Molecular Weight: 41.5 kDa

UniProt: P01868