ILDR2 Protein (Fc Tag)

Catalog No. ABIN7319797

Recombinant ILDR2 protein expressed in Human Cells.

Quick Overview for ILDR2 Protein (Fc Tag) (ABIN7319797)

Target: ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This ILDR2 protein is labelled with Fc Tag.

Purpose: Recombinant Human ILDR2 (C-Fc)

Sequence: Leu21-Glu186

Characteristics: Recombinant Human Immunoglobulin-like Domain-containing Receptor 2 is produced by our Mammalian expression system and the target gene encoding Leu21-Glu186 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))

Alternative Name: ILDR2

Background:

Background: ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99 % and 98 % homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23-25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation). Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.

Synonym: Angulin-3, C1orf32, Dbsm1, DJ782G3.1, ILDR2, immunoglobulin-like domain containing receptor 2, LISCH-Like

Molecular Weight: 45.8 kDa

UniProt: Q71H61