ILDR2 Protein (His tag)
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- Target See all ILDR2 products
- ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This ILDR2 protein is labelled with His tag.
- Purpose
- Recombinant Human ILDR2 (C-6His)
- Sequence
- Leu21-Glu186
- Characteristics
- Recombinant Human Immunoglobulin-like Domain-containing Receptor 2 is produced by our Mammalian expression system and the target gene encoding Leu21-Glu186 is expressed with a 6His tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 21-184) protein (Fc Tag)
ILDR2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 92 % as determined by HPLC
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 21-186) protein (His tag)Crystallography grade ILDR2 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, Crys, ELISA, WB
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 36-201) protein (His tag)Crystallography grade ILDR2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, Crys, ELISA, WB
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 208-639) protein (His tag)Crystallography grade ILDR2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, Crys, ELISA, WB
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 223-661) protein (His tag)Crystallography grade ILDR2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, Crys, ELISA, WB
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 21-639) protein (rho-1D4 tag)Crystallography grade ILDR2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, Crys, ELISA, WB
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 36-661) protein (rho-1D4 tag)Crystallography grade ILDR2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, Crys, ELISA, WB
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 21-186) protein (Fc Tag)ILDR2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 1-186), (Extracellular) protein (GST tag)ILDR2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2) (AA 1-186), (Extracellular) protein (His tag)ILDR2 Origin: Human Host: Yeast Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2))
- Alternative Name
- ILDR2 (ILDR2 Products)
- Synonyms
- C1orf32 Protein, RP4-782G3.2 Protein, dJ782G3.1 Protein, immunoglobulin like domain containing receptor 2 Protein, ILDR2 Protein
- Background
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Background: ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99 % and 98 % homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23-25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation). Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.
Synonym: Angulin-3, C1orf32, Dbsm1, DJ782G3.1, ILDR2, immunoglobulin-like domain containing receptor 2, LISCH-Like
- Molecular Weight
- 19.5 kDa
- UniProt
- Q71H61
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