Insulin Protein (INS)
Quick Overview for Insulin Protein (INS) (ABIN7318503)
Target
See all Insulin (INS) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purpose
- Recombinant Human Insulin Protein (Active)
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Sequence
- Phe1-Lys29&Gly1-Asn21
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Characteristics
- A DNA sequence encoding human insulin B chain (2LGB_B)(Phe1-Lys29) and human insulin A chain (2KXK_A)(Gly1-Asn21) was expressed with a linker AAK.
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Biological Activity Comment
- Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells.The ED50 for this effect is typically 0.2-1 μg/mL.
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Insulin (INS) protein
INS Origin: Human Host: Yeast Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Insulin (INS) (AA 1-110) protein (GST tag)INS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Insulin (INS) (AA 25-54), (AA 90-110) (Active) protein (His tag)INS Origin: Mouse Host: Escherichia coli (E. coli) > 97 % AcA, CC Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Insulin (INS)
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Alternative Name
- Insulin
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Background
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Background: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: IDDM;IDDM1;IDDM2;ILPR;INS;IRDN;MODY10
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Molecular Weight
- 6 kDa
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UniProt
- P01308
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Pathways
- NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Target
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