ITM2B Protein (AA 76-266) (His tag)

Catalog No. ABIN7318631

Recombinant ITM2B protein expressed in HEK-293 Cells.

Quick Overview for ITM2B Protein (AA 76-266) (His tag) (ABIN7318631)

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 76-266

Purification tag / Conjugate: This ITM2B protein is labelled with His tag.

Purpose: Recombinant Human ITM2B Protein (His Tag)

Sequence: Tyr76-Ser266

Characteristics: Recombinant Human Integral Membrane Protein 2B is produced by our Mammalian expression system and the target gene encoding Tyr76-Ser266 is expressed with a 6His tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Acetate, 10 % Trehalose, 25 mM NaCl, 10 % Glycerol, 0.05 % Tween 80, pH 4.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Alternative Name: ITM2B

Background: BRI,BRI2,Bri,ITM2B,Immature BRI2,Integral Membrane Protein 2B,Protein E25B,Transmembrane Protein BRI,imBRI2,Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.

Molecular Weight:

Calculated MW: 23.3 kDa

Observed MW: 29-33 kDa

Gene ID: 9445

UniProt: Q9Y287