IL1RAPL2 Protein (His tag)

Catalog No. ABIN7196312

Recombinant IL1RAPL2 protein expressed in HEK-293 Cells.

Quick Overview for IL1RAPL2 Protein (His tag) (ABIN7196312)

Target: IL1RAPL2 (Interleukin 1 Receptor Accessory Protein-Like 2 (IL1RAPL2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: > 98 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This IL1RAPL2 protein is labelled with His tag.

Purpose: Recombinant Human IL-1R9/IL1RAPL2 Protein (His Tag)(Active)

Sequence: Met 1-Glu 356

Characteristics: A DNA sequence encoding the extracellular domain (Met 1-Glu 356) of human IL1R9 (NP_059112.1) was expressed, with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind biotinylated human IL1α in functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL1RAPL2 (Interleukin 1 Receptor Accessory Protein-Like 2 (IL1RAPL2))

Alternative Name: IL-1R9/IL1RAPL2

Background:

Background: X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL, which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci, and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.

Synonym: IL-1R9,IL1R9,IL1RAPL-2,TIGIRR-1

Molecular Weight: 40.7 kDa

NCBI Accession: NP_059112