IL1RL1 Protein
Quick Overview for IL1RL1 Protein (ABIN7318037)
Target
See all IL1RL1 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human IL1RL1/ST2 Protein
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Sequence
- Met 1-Phe 328
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Characteristics
- The secreted isoform of human IL1RL1 (NP_003847.2) (Met 1-Phe 328) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) protein (His tag)
IL1RL1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) (Active) protein (His tag)IL1RL1 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 1 Receptor-Like 1 (IL1RL1) protein (His tag)IL1RL1 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 1-328) (Active) protein (Fc Tag)IL1RL1 Origin: Human Host: HEK-293 Cells Recombinant >90 % (SDS-PAGE) SDS Active
Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) protein (His tag)IL1RL1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS
Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-323) (Active) protein (Fc Tag)IL1RL1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
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Alternative Name
- IL1RL1/ST2
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Background
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Background: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
Synonym: DER4;FIT-1;IL1RL1;IL33R;IL-1 R4;ST2;ST2L;ST2V;T1
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Molecular Weight
- 35.6 kDa
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NCBI Accession
- NP_003847
Target
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