IL17D Protein

Catalog No. ABIN7319563

Product Details

Target: IL17D (Interleukin 17D (IL17D))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human Interleukin-17D/IL-17D Protein

Sequence: Ala18-Pro202

Characteristics: Recombinant Human Interleukin-17D is produced by our E.coli expression system and the target gene encoding Ala18-Pro202 is expressed.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL17D (Interleukin 17D (IL17D))

Alternative Name: Interleukin-17D/IL-17D (IL17D Products)

Synonyms: IL-17D Protein, IL-22 Protein, IL-27 Protein, IL27 Protein, AI462269 Protein, Il27a Protein, il17-4 Protein, zgc:194257 Protein, zgc:194303 Protein, IL-27p28 Protein, Il30 Protein, p28 Protein, interleukin 17D Protein, interleukin 17d Protein, interleukin 27 Protein, IL17D Protein, Il17d Protein, il17d Protein, Il27 Protein

Background:

Background: The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27 % aa sequence homology. IL-17D is expressed preferentially in skeletal muscle, heart, adipose tissue, lung, pancreas, and nervous system. Like other IL-17 family members, IL-17D modulates immune responses indirectly by stimulating the production of myeloid growth factors and chemokines including IL-6, IL-8, and GM-CSF. IL-17D has also been shown to suppress the proliferation of myeloid progenitors in colony formation assays.

Synonym: Interleukin-17D, IL-17D,IL17D

Molecular Weight: 20.3 kDa

UniProt: Q8TAD2

Pathways: Cellular Response to Molecule of Bacterial Origin