IL3RA Protein (Fc Tag)

Catalog No. ABIN7321046

This Recombinant IL3RA protein is produced in Human Cells.

Quick Overview for IL3RA Protein (Fc Tag) (ABIN7321046)

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Protein Type: Recombinant

Origin: Cynomolgus

Source: Human Cells

Purity: >95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This IL3RA protein is labelled with Fc Tag.

Purpose: Recombinant Cynomolgus IL-3 Receptor Subunit Alpha/IL-3RA/CD123 (C-Fc)

Sequence: Arg18-Arg302

Characteristics: Recombinant Cynomolgus Interleukin-3 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Arg18-Arg302 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Alternative Name: IL-3 Receptor Subunit Alpha/IL-3RA/CD123

Background:

Background: CD123, also known as Interleukin-3 receptor subunit alpha, belongs to the type I cytokine receptor family. In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage-committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit does not bind IL-3 by itself but is required for the high-affinity binding of IL-3 to the heterodimeric receptor complex.

Synonym: Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, CD123

Molecular Weight: 33.6 kDa

UniProt: G8F3K3

Pathways: JAK-STAT Signaling