Quick Overview for IL6RA Protein (His tag) (ABIN7320911)
Target
See all IL6RA ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This IL6RA protein is labelled with His tag.
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Purpose
- Recombinant Mouse IL-6 Receptor Subunit alpha/IL-6RA/CD126 (C-6His)
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Sequence
- Leu20-Pro364
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Characteristics
- Recombinant Mouse Interleukin-6 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Leu20-Pro364 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His-Avi Tag)
IL6RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (Biotin,His-Avi Tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (hFc Tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) protein (Fc Tag,ECD)IL6RA Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Interleukin 6 Receptor, alpha (IL6RA) (Active) protein (His tag,ECD)IL6RA Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Interleukin 6 Receptor, alpha (IL6RA) protein (Fc Tag)IL6RA Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag,AVI tag,Biotin)IL6RA Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (Fc Tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-357) (Active) protein (His tag,AVI tag,Biotin)IL6RA Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
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Alternative Name
- IL-6 Receptor Subunit alpha/IL-6RA/CD126
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Background
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Background: Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
Synonym: Interleukin-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6R 1, Membrane glycoprotein 80, gp80, CD126
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Molecular Weight
- 38.9 kDa
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UniProt
- P22272
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Pathways
- JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
Target
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