Quick Overview for IL6RA Protein (Fc Tag,ECD) (ABIN7196591)
Target
See all IL6RA ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This IL6RA protein is labelled with Fc Tag,ECD.
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Purpose
- Recombinant Rat IL6RA/CD126 Protein (Fc tag, ECD)
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Sequence
- Met1-Pro364
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Characteristics
- A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with the Fc region of human IgG1 at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg protein as determined by the LAL method.
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Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His-Avi Tag)
IL6RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (Biotin,His-Avi Tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (hFc Tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) protein (His tag)IL6RA Origin: Mouse Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 6 Receptor, alpha (IL6RA) (Active) protein (His tag,ECD)IL6RA Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Interleukin 6 Receptor, alpha (IL6RA) protein (Fc Tag)IL6RA Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag,AVI tag,Biotin)IL6RA Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (Fc Tag)IL6RA Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-357) (Active) protein (His tag,AVI tag,Biotin)IL6RA Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
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Alternative Name
- IL6RA/CD126
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Background
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Background: Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Il6ra;IL-6R
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Molecular Weight
- 64.8 kDa
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NCBI Accession
- NP_058716
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Pathways
- JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
Target
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