JTB Protein (Fc Tag)
Quick Overview for JTB Protein (Fc Tag) (ABIN7317243)
Target
See all JTB ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This JTB protein is labelled with Fc Tag.
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Purpose
- Recombinant Human Jumping Translocation Breakpoint/JTB Protein (Fc Tag)
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Sequence
- Met 1-Leu105
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Characteristics
- A DNA sequence encoding the human JTB (O76095-1) (Met1-Leu105) was fused with Fc region of mouse IgG at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Jumping Translocation Breakpoint (JTB) (AA 31-105) protein (His-IF2DI Tag)
JTB Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Jumping Translocation Breakpoint (JTB) (AA 1-146) protein (GST tag)JTB Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Jumping Translocation Breakpoint (JTB) (AA 31-105) protein (His tag)JTB Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- JTB (Jumping Translocation Breakpoint (JTB))
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Alternative Name
- Jumping Translocation Breakpoint/JTB
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Background
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Background: Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
Synonym: hJT,HJTB,HSPC222,JTB,PAR
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Molecular Weight
- 34.7 kDa
Target
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