KIT Ligand Protein (KITLG) (His tag)

Catalog No. ABIN7321269

This Recombinant KIT Ligand protein is produced in Human Cells.

Quick Overview for KIT Ligand Protein (KITLG) (His tag) (ABIN7321269)

Target: KIT Ligand (KITLG)

Protein Type: Recombinant

Origin: Rat

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This KIT Ligand protein is labelled with His tag.

Purpose: Recombinant Rat SCF/c-Kit Ligand Protein (Human Cells, His Tag)

Sequence: Gln26-Ala189

Characteristics: Recombinant Rat SCF is produced by our Mammalian expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: KIT Ligand (KITLG)

Alternative Name: SCF/c-Kit Ligand

Background:

Background: SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

Synonym: FPH2, KIT ligand, Kitl, KITLG, KL-1, Mast cell growth factor, MGF, MGFSHEP7, SCF, SFc-Kit ligand, SLF, steel factor, Stem Cell Factor, c-kit Ligand

Molecular Weight: 19.4 kDa

UniProt: P21581

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway