LYPD3 Protein (His tag)

Catalog No. ABIN7320237

This Recombinant LYPD3 protein is expressed in HEK-293 Cells.

Quick Overview for LYPD3 Protein (His tag) (ABIN7320237)

Target: LYPD3 (LY6/PLAUR Domain Containing 3 (LYPD3))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purity: > 92 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This LYPD3 protein is labelled with His tag.

Purpose: Recombinant Mouse LYPD3 Protein (His Tag)(Active)

Sequence: Met 1-His 287

Characteristics: A DNA sequence encoding the N-terminal segment of mouse LYPD3 (NP_598504.1) (Met 1-His 287) was expressed, with a polyhistidine tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind recombinant human Galectin3 in a functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: LYPD3 (LY6/PLAUR Domain Containing 3 (LYPD3))

Alternative Name: LYPD3

Background:

Background: Ly6 / PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4 and LYPD3, is a cell membrane protein which contains two UPAR/Ly6 domains. Human LYPD3 contains two UPAR/Ly6 domains. LYPD3 is expressed in placenta, skin and urothelium. It is found in suprabasal keratinocytes of chronic wounds. Weak expression of LYPD3 is found in esophagus and peripheral blood mononuclear cells. It is found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression of LYPD3 is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. LYPD3 is up-regulated in migrating keratinocytes during epithelisation of incisional skin wounds. LYPD3 supports cell migration. It may be involved in urothelial cell-matrix interactions. It may also be involved in tumor progression

Synonym: 2310061G07Rik;C4.4a

Molecular Weight: 28 kDa

NCBI Accession: NP_598504