MBL2 Protein

Catalog No. ABIN7196928

This Recombinant MBL2 protein is produced in CHO Cells.

Quick Overview for MBL2 Protein (ABIN7196928)

Target: MBL2 (Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2))

Protein Type: Recombinant

Origin: Human

Source: CHO Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human MBL2/MBL/COLEC1 Protein

Sequence: Met 1-Ile 248

Characteristics: A DNA sequence encoding the human MBL (NP_000233.1) (Met1-Ile 248) was expressed.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: MBL2 (Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2))

Alternative Name: MBL2/MBL/COLEC1

Background: COLEC1,Collectin-1,HSMBPC,MBL,MBL2,MBL2D,MBP,MBP-C,MBP1,MBPD,Mannan-Binding Protein,Mannose-Binding Lectin,Mannose-Binding Protein C,MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

Molecular Weight:

Calculated MW: 24 kDa

Observed MW: 31 kDa

Gene ID: 4153

NCBI Accession: NP_000233

UniProt: P11226

Pathways: Complement System, Positive Regulation of Immune Effector Process