MVK Protein (His-GST)
Quick Overview for MVK Protein (His-GST) (ABIN7197016)
Target
See all MVK ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This MVK protein is labelled with His-GST.
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Purpose
- Recombinant Human MVK/Mevalonate kinase Protein (His & GST Tag)
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Sequence
- Met 1-Leu 396
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Characteristics
- A DNA sequence encoding the human MVK (Q03426) (Met1-Leu396) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Mevalonate Kinase (MVK) (AA 1-395) protein (His tag)
custom-made MVK Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mevalonate Kinase (MVK) (AA 1-396) protein (His tag)custom-made MVK Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mevalonate Kinase (MVK) (AA 1-396) protein (GST tag)MVK Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Mevalonate Kinase (MVK) (AA 1-396) protein (His tag)MVK Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Mevalonate Kinase (MVK) proteinMVK Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS
Mevalonate Kinase (MVK) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)MVK Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Mevalonate Kinase (MVK) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)MVK Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 2 mM DTT, pH 7.4, 10 % glycerol
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Preservative
- Dithiothreitol (DTT)
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Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- MVK (Mevalonate Kinase (MVK))
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Alternative Name
- MVK/Mevalonate kinase
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Background
- LRBP,MK,MVLK,POROK3,Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in mevalonate kinase can also cause hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis.
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Molecular Weight
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Calculated MW: 70.2 kDa
Observed MW: 47 kDa
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Gene ID
- 4598
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UniProt
- Q03426
Target
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