MAPK12 Protein
Quick Overview for MAPK12 Protein (ABIN7317045)
Target
See all MAPK12 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human ERK3/MAPK12 Protein
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Sequence
- Met 1-Leu 367
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Characteristics
- A DNA sequence encoding the human MAPK12 (P53778) (Met1-Leu367) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)
custom-made MAPK12 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)custom-made MAPK12 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His-IF2DI Tag)MAPK12 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (GST tag)MAPK12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA, KAA
Mitogen-Activated Protein Kinase 12 (MAPK12) protein (GST tag,His tag)MAPK12 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) protein (His tag)MAPK12 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
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Alternative Name
- ERK3/MAPK12
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Background
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Background: ERK3; also known as MAPK12 and p38-gamma; belongs to the protein kinase superfamily; CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly; p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1; prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Synonym: ERK-6;ERK3;ERK6;MAPK12;P38GAMMA;PRKM12;SAPK-3;SAPK3;P38-gamma
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Molecular Weight
- 42.1 kDa
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UniProt
- P53778
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Pathways
- MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C, BCR Signaling, S100 Proteins
Target
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