Neurexophilin 1 Protein (NXPH1) (His tag)

Catalog No. ABIN7321231

This Recombinant Neurexophilin 1 protein is produced in HEK-293 Cells.

Quick Overview for Neurexophilin 1 Protein (NXPH1) (His tag) (ABIN7321231)

Target: Neurexophilin 1 (NXPH1)

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purity: > 92 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Neurexophilin 1 protein is labelled with His tag.

Purpose: Recombinant Rat Neurexophilin-1/NXPH1 Protein (His Tag)

Sequence: Met 1-Gly 271

Characteristics: A DNA sequence encoding the rat NXPH1 (Q63366-1) (Met 1-Gly 271) was expressed, fused with a polyhistidine tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Neurexophilin 1 (NXPH1)

Alternative Name: Neurexophilin-1/NXPH1

Background: MGC124635,Neurexophilin-1, or NXPH1 is a secreted glycoprotein, which belongs to the Neurexophilin family. The Neurexophilin family contain at least four genes and resembles a neuropeptide, suggesting a function as an endogenous ligand for alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains: an N-terminal signal peptide, a variable N-terminal domain, a highly conserved central domain that is N-glycosylated, a short linker region, and a conserved C-terminal domain that is cysteine-rich. Neurexophilin-1 constitutes a secreted cysteine-rich glycoprotein, forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. Neurexophilins 1 and 3 but not 4 (neurexophilin 2 is not expressed in rodents) bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins.

Molecular Weight:

Calculated MW: 30.0 kDa

Observed MW: 45-50 kDa

Gene ID: 25501

UniProt: Q63366