NFASC Protein (His tag)
Quick Overview for NFASC Protein (His tag) (ABIN7317169)
Target
See all NFASC ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This NFASC protein is labelled with His tag.
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Purpose
- Recombinant Human NFASC/Neurofascin protein (His Tag)
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Sequence
- Met 1-Gln939
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Characteristics
- A DNA sequence encoding the human NFASC (O94856-12) (Met1-Gln939) was expressed with a C-terminal polyhistidine tag.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Neurofascin (NFASC) protein (Fc Tag)
NFASC Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Neurofascin (NFASC) (AA 1239-1347) protein (His tag)NFASC Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
Neurofascin (NFASC) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NFASC Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Neurofascin (NFASC) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)NFASC Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- NFASC (Neurofascin (NFASC))
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Alternative Name
- NFASC/Neurofascin
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Background
- NF,NRCAML,NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
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Molecular Weight
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Calculated MW: 104.4 kDa
Observed MW: 114-119 kDa
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UniProt
- O948562
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Pathways
- Cell-Cell Junction Organization
Target
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