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Neuroligin 1 Protein (NLGN1) (His tag)

NLGN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE
Catalog No. ABIN7320172
  • Target See all Neuroligin 1 (NLGN1) Proteins
    Neuroligin 1 (NLGN1)
    Protein Type
    Recombinant
    Origin
    • 10
    • 3
    Mouse
    Source
    • 6
    • 3
    • 2
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This Neuroligin 1 protein is labelled with His tag.
    Purpose
    Recombinant Mouse Neuroligin 1/NLGN1 Protein (His Tag)
    Sequence
    Met 1-Ser 697
    Characteristics
    A DNA sequence encoding the mouse NLGN1 isoform 1 (Q99K10-1) extracellular domain (Met 1-Ser 697) was expressed, with a C-terminal polyhistidine tag.
    Purity
    > 97 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product NLGN1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Neuroligin 1 (NLGN1)
    Alternative Name
    Neuroligin 1/NLGN1 (NLGN1 Products)
    Synonyms
    NLGN1 Protein, Nlgn1 Protein, GB18720 Protein, nlgn1 Protein, NL1 Protein, 6330415N05Rik Protein, BB179718 Protein, mKIAA1070 Protein, neuroligin-1 Protein, neuroligin 1 Protein, NLGN1 Protein, LOC659779 Protein, LOC724358 Protein, nlgn1 Protein, Nlgn1 Protein
    Background

    Background: Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consist of five members (NLGN1, NLGN2, NLGN3, NLGN4 and NLGN4Y), which interact with beta-neurexins and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.

    Synonym: 6330415N05Rik,BB179718,mKIAA1070,NL1,Nlg1

    Molecular Weight
    73.5 kDa
    Pathways
    Synaptic Membrane, Synaptic Vesicle Exocytosis
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