PON3 Protein (His tag)

Catalog No. ABIN7317316

This Recombinant PON3 protein is produced in Baculovirus infected Insect Cells.

Quick Overview for PON3 Protein (His tag) (ABIN7317316)

Target: PON3 (Paraoxonase 3 (PON3))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purity: > 85 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This PON3 protein is labelled with His tag.

Purpose: Recombinant Human PON3/Paraoxonase 3 Protein (50 Ser/Asn, His Tag)

Sequence: Met 1-Leu 354

Characteristics: A DNA sequence encoding the human PON3 (Q15166-1) (Met 1-Leu 354) (50 Ser/Asn) was expressed, with a polyhistidine tag at the N-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 1 mM CaCL2, 10 % glycerol, 0.1 % DDM

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: PON3 (Paraoxonase 3 (PON3))

Alternative Name: PON3/Paraoxonase 3

Background:

Background: KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.

Synonym: PON3

Molecular Weight: 42 kDa

Pathways: Monocarboxylic Acid Catabolic Process