PSPH Protein
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- Target See all PSPH Proteins
- PSPH (Phosphoserine Phosphatase (PSPH))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human PSPH Protein
- Sequence
- Met 1-Glu 225
- Characteristics
- A DNA sequence encoding the human PSPH (P78330) (Met 1-Glu 225) was expressed and purified.
- Purity
- > 84 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PSPH Protein
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Phosphoserine Phosphatase (PSPH) (AA 1-225) protein (GST tag)
PSPH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Phosphoserine Phosphatase (PSPH) (AA 1-100) protein (GST tag)PSPH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Phosphoserine Phosphatase (PSPH) protein (Myc-DYKDDDDK Tag)PSPH Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.5
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- PSPH (Phosphoserine Phosphatase (PSPH))
- Alternative Name
- PSPH (PSPH Products)
- Synonyms
- PSP Protein, PSPHD Protein, AI480570 Protein, PSPase Protein, PSPH Protein, psph Protein, MGC78828 Protein, zgc:112414 Protein, DDBDRAFT_0183847 Protein, DDBDRAFT_0230054 Protein, DDB_0183847 Protein, DDB_0230054 Protein, phosphoserine phosphatase Protein, phosphoserine phosphatase L homeolog Protein, PSP; O-phosphoserine phosphohydrolase; PSPase Protein, phosphoserine phosphatase SerB Protein, BPI fold containing family A member 2 Protein, PSPH Protein, Psph Protein, psph.L Protein, psph Protein, serB Protein, serB-1 Protein, LOC5568588 Protein, PSP Protein, Svir_29300 Protein, MMAH_RS03435 Protein, BPIFA2 Protein
- Background
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Background: Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine phosphatase (PSPH) is expressed throughout the proliferative layer of the epidermis and hair follicles in rodent and human skin and is highly induced in SCC. In keratinocytes, Phosphoserine phosphatase (PSPH) is a cytoplasmic protein that primarily localizes to endosomes and is present primarily as a homodimer. Knock down of Phosphoserine phosphatase (PSPH) dramatically diminished SCC cell proliferation and cyclin D1 levels in the presence of exogenous of l-serine production suggesting a non-canonical role for Phosphoserine phosphatase (PSPH) in epithelial carcinogenesis. Phosphoserine phosphatase (PSPH) is highly induced in proliferative normal keratinocytes and in skin tumors. Phosphoserine phosphatase (PSPH) appears to be critical for the proliferation of SCC cells, however, this phenomenon may not involve the phosphoserine metabolic pathway.
Synonym: Phosphoserine Phosphatase, PSP, PSPase, L-3-Phosphoserine Phosphatase, O-Phosphoserine Phosphohydrolase, PSPH
- Molecular Weight
- 25 kDa
- UniProt
- P78330
- Pathways
- Warburg Effect
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