PVRIG Protein (mFc Tag)
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- Target See all PVRIG Proteins
- PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This PVRIG protein is labelled with mFc Tag.
- Purpose
- Recombinant Human PVRIG (C-mFc)
- Sequence
- Thr41-Asp171
- Characteristics
- Recombinant Human Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Thr41-Asp171 is expressed with a mFc tag at the C-terminus.
- Purity
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1.Immobilized Human PVRIG-mFc(Cat#C08Y) at 10μg/ml (100 μl/well) can bind Human Nectin-2-His(Cat#C440).The ED50 of Human Nectin-2-His(Cat#C440) is 3.72 ug/ml. 2.Immobilized Human PVRIG-mFc(Cat#C08Y) at 10μg/ml (100 μl/well) can bind Biotinylated Human Nectin-2-His-Avi(Cat#CY73). The ED50 of Biotinylated Human Nectin-2-His-Avi(Cat#CY73) is 0.42 ug/ml.
- Top Product
- Discover our top product PVRIG Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- PVRIG (Poliovirus Receptor-Related Immunoglobulin Domain Containing (PVRIG))
- Alternative Name
- PVRIG (PVRIG Products)
- Synonyms
- C7orf15 Protein, PVR related immunoglobulin domain containing Protein, PVRIG Protein
- Background
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Background: Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65 % similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Synonym: C7orf15, CD112R, PVRIG, transmembrane protein PVRIG, C7orf15MGC138295, MGC104322, MGC138297, MGC2463
- Molecular Weight
- 40.1 kDa
- UniProt
- Q6DKI7
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