PKD2 Protein (His-GST)
Quick Overview for PKD2 Protein (His-GST) (ABIN7317066)
Target
See all PKD2 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This PKD2 protein is labelled with His-GST.
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Purpose
- Recombinant Human PRKD2/PKD2 Protein (His & GST Tag)
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Sequence
- Met 1-Leu 878
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Characteristics
- A DNA sequence encoding the amino acid sequence (Met 1-Leu 878) of human PRKD2 (NP_057541.2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be > 30 nmol/min/mg using synthetic CREBtide peptide (KRREILSRRPSYR) as substrate.
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Protein Kinase D2 (PKD2) (AA 1-878) protein (GST tag)
PKD2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Protein Kinase D2 (PKD2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PKD2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Protein Kinase D2 (PKD2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PKD2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as sterile solution of 50 mM Tris, 500 mM NaCl, 0.5 mM PMSF, 10 % glycerol, pH 8.0
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Preservative
- PMSF
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- PKD2 (Protein Kinase D2 (PKD2))
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Alternative Name
- PRKD2/PKD2
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Background
- HSPC187,PKD2,nPKC-D2,Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains onePH domain, twophorbol-ester/DAG-type zinc fingers and oneprotein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-710 and phosphorylation of Ser-706 by PKC relieves auto-inhibition by the PH domain. PRKD2 / PKD2 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.
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Molecular Weight
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Calculated MW: 124 kDa
Observed MW: 120 kDa
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Gene ID
- 25865
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NCBI Accession
- NP_057541
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UniProt
- Q9BZL6
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Pathways
- cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
Target
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