PTPN12 Protein
Quick Overview for PTPN12 Protein (ABIN7317537)
Target
See all PTPN12 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purpose
- Recombinant Human PTPN12 Protein (Active)
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Sequence
- Met 1-Gln355
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Characteristics
- A DNA sequence encoding the human PTPN12 (AAA36529.1) (Met1-Gln355) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site .The specific activity is >20 mol/min/mg
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Protein Tyrosine Phosphatase G1 (PTPN12) (AA 1-775) protein (His tag)
custom-made PTPN12 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Protein Tyrosine Phosphatase G1 (PTPN12) (AA 1-780) protein (His tag)custom-made PTPN12 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Protein Tyrosine Phosphatase G1 (PTPN12) (AA 2-300) protein (His tag)PTPN12 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Protein Tyrosine Phosphatase G1 (PTPN12) (AA 1-780) protein (GST tag)PTPN12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
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Alternative Name
- PTPN12
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Background
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Background: PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. PTPN12 was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobilit.
Synonym: PTP-PEST,PTPG1
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Molecular Weight
- 41.8 kDa
Target
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