Relaxin 1 Protein (RLN1) (His tag)

Catalog No. ABIN7317519

This Recombinant Relaxin 1 protein is expressed in HEK-293 Cells.

Quick Overview for Relaxin 1 Protein (RLN1) (His tag) (ABIN7317519)

Target: Relaxin 1 (RLN1)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 82 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Relaxin 1 protein is labelled with His tag.

Purpose: Recombinant Human Relaxin-1/RLN1 Protein (His Tag)

Sequence: Met 1-Cys 185

Characteristics: A DNA sequence encoding the human RLN1 (NP_008842.1) (Met 1-Cys 185) was fused with a polyhistidine tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Relaxin 1 (RLN1)

Alternative Name: Relaxin-1/RLN1

Background: H1,H1RLX,RLN1,RLXH1,bA12D24.3.1,bA12D24.3.2,Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein which belongs to theinsulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 80 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has important implications in several nonreproductive organs, including the heart, lung, kidney, liver and skin. The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity, relaxin-1 (RNL1), relaxin-2 (RNL2) and relaxin-3 ( RNL3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised. Relaxin-1 / RLN1 is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Relaxin-1 / RLN1 may be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Relaxin and estrogen appear to play protective roles against airway fibrosis, airway SM thickening, and cardiac hypertrophy. Relaxin may also provide a means to regulate excessive collagen deposition during kidney development and in diseased states characterized by renal fibrosis.

Molecular Weight:

Calculated MW: 20.0 kDa

Observed MW: 20 kDa

Gene ID: 6013

NCBI Accession: NP_008842

UniProt: P04808