Quick Overview for Renin Protein (REN) (His tag) (ABIN7320778)
Target
See all Renin (REN) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This Renin protein is labelled with His tag.
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Purpose
- Recombinant Mouse REN1/Renin-1 Protein (His Tag)
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Sequence
- Leu22-Arg402
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Characteristics
- Recombinant Mouse Renin is produced by our Mammalian expression system and the target gene encoding Leu22-Arg402 is expressed with a 10His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Renin (REN) (AA 24-406) protein (GST tag)
REN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Renin (REN) (Active) protein (His tag)REN Origin: Mouse Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Renin (REN) (AA 24-406) protein (His tag)REN Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Renin (REN)
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Alternative Name
- REN1/Renin-1
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Background
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Background: Mouse Renin, also known as Renin-1,is a member of the peptidase A1 amily. Renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. It cleaves angiotensinogen to generate angiotensin I, which can be further converted by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II is the active molecule of the reninangiotensin system that acts by binding to angiotensin receptors type 1 and 2 (AT1 and AT2),and has direct pathophysiological effects on the heart and peripheral vasculature. After secretion, inactive prorenin can be proteolytically activated by trypsin, cathepsin B, or other proteinases.
Synonym: Renin-1, Angiotensinogenase, Kidney renin, Ren1, Ren, Ren-1,Angiotensin-forming enzyme,Ren-A,Ren1c,Ren1d,Rn-1,Rnr
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Molecular Weight
- 43.5 kDa
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UniProt
- P06281
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Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
Target
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