RNASET2 Protein (His tag)
Quick Overview for RNASET2 Protein (His tag) (ABIN7319474)
Target
See all RNASET2 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This RNASET2 protein is labelled with His tag.
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Purpose
- Recombinant Human RNASET2 Protein (Human Cells, His Tag)
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Sequence
- Asp25-His256
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Characteristics
- Recombinant Human Ribonuclease T2 is produced by our Mammalian expression system and the target gene encoding Asp25-His256 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Ribonuclease T2 (RNASET2) (AA 172-256) protein (His-IF2DI Tag)
RNASET2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Ribonuclease T2 (RNASET2) (AA 1-256) protein (GST tag)RNASET2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Ribonuclease T2 (RNASET2) protein (Myc-DYKDDDDK Tag)RNASET2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHcl, 150 mM NaCl,20 % Glycerol, pH 7.5.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- RNASET2 (Ribonuclease T2 (RNASET2))
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Alternative Name
- RNASET2
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Background
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Background: RNASET2 (ribonuclease T2) is an enzyme which belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. This protein can be inhibited by Zn2+ and Cu2+. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.
Synonym: Ribonuclease T2,3.1.27.-,Ribonuclease 6,RNASE6PL
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Molecular Weight
- 28.2 kDa
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UniProt
- O00584
Target
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