S100A7A Protein (His-MBP)

Catalog No. ABIN7320360

This Recombinant S100A7A protein is produced in Escherichia coli (E. coli).

Quick Overview for S100A7A Protein (His-MBP) (ABIN7320360)

Target: S100A7A (S100 Calcium Binding Protein A7A (S100A7A))

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This S100A7A protein is labelled with His-MBP.

Purpose: Recombinant Mouse S100A15/S100A7A Protein (His & MBP Tag)

Sequence: Met 1-Tyr 108

Characteristics: A DNA sequence encoding the mouse S100A7A (Q6S5I3) (Met 1-Tyr 108) was fused with the N-terminal polyhistidine-tagged MBP tag at the N-terminus.

Sterility: 0.2 μm filtered

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: S100A7A (S100 Calcium Binding Protein A7A (S100A7A))

Alternative Name: S100A15/S100A7A

Background: AY465109,Gm1020,S100A7L1,S100A7f,S100a15,S100a15a,S100a17l1,Koebnerisin is also known as protein S100-A7A (S100A7A), S100 calcium-binding protein A7-like 1 (S100A7L1) or S100 calcium-binding protein A15 (S100A15). Human S100A7A / S100A15 is a novel member of the S100 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype. The association of the 11.2 kDa S100A7A / S100A15 with psoriasis suggests that it contributes to the pathogenesis of the disease and could provide a molecular target for therapy.

Molecular Weight:

Calculated MW: 56.5 kDa

Observed MW: 50 kDa

UniProt: Q6S5I3

Pathways: Activation of Innate immune Response, S100 Proteins