STUB1 Protein
Quick Overview for STUB1 Protein (ABIN7318418)
Target
See all STUB1 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human STUB1 Protein
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Sequence
- Met 1-Tyr303
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Characteristics
- Recombinant Human E3 Ubiquitin-Protein Ligase CHIP is produced by our E.coli expression system and the target gene encoding Met1-Tyr303 is expressed.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His-IF2DI Tag)
STUB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)STUB1 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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Alternative Name
- STUB1
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Background
- Antigen NY-CO-7,CHIP,CLL-Associated Antigen KW-8,Carboxy Terminus of Hsp70-Interacting Protein,E3 Ubiquitin-Protein Ligase CHIP,STIP1 Homology and U Box-Containing Protein 1,STUB1,E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
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Molecular Weight
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Calculated MW: 34.9 kDa
Observed MW: 33 kDa
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Gene ID
- 10273
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UniProt
- Q9UNE7
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Pathways
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
Target
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