Quick Overview for TIMP1 Protein (ABIN7320662)
Target
See all TIMP1 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Mouse TIMP1/TIMP Protein
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Sequence
- Cys25-Arg205
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Characteristics
- Recombinant Mouse Tissue Inhibitors of Metalloproteinases 1 is produced by our Mammalian expression system and the target gene encoding Cys25-Arg205 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 25-205) protein (Fc Tag)
TIMP1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 1-169) protein (GST tag)TIMP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (AA 24-207) protein (Fc Tag)TIMP1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (Active) proteinTIMP1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
TIMP Metallopeptidase Inhibitor 1 (TIMP1) (Active) proteinTIMP1 Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
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Alternative Name
- TIMP1/TIMP
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Background
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Background: Mouse Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) is a member of TIMP family. The homologous proteins of TIMPs regulate the activity of matrix metalloproteinases (MMPs), including inhibition of active MMPs, proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Timp-1 complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. It also mediates erythropoiesis in vitro, but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16, without MMP-14.
Synonym: Metalloproteinase Inhibitor 1, Erythroid-Potentiating Activity, EPA, Fibroblast collagenase Inhibitor, Collagenase Inhibitor, Tissue Inhibitor of Metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP
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Molecular Weight
- 20.2 kDa
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UniProt
- P12032
Target
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