VNN1 Protein (His tag)
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- Target See all VNN1 Proteins
- VNN1 (Vanin 1 (VNN1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This VNN1 protein is labelled with His tag.
- Purpose
- Recombinant Human VNN1/Vanin-1 Protein (His Tag)
- Sequence
- Gln22-Ser490
- Characteristics
- Recombinant Human Vascular Non-Inflammatory Molecule 1 is produced by our Mammalian expression system and the target gene encoding Gln22-Ser490 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product VNN1 Protein
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Vanin 1 (VNN1) (AA 1-513) protein (GST tag)
VNN1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Vanin 1 (VNN1) (AA 298-397) protein (GST tag)VNN1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Vanin 1 (VNN1) protein (Fc Tag)VNN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE
Vanin 1 (VNN1) (AA 22-491) protein (His tag)Crystallography grade VNN1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- VNN1 (Vanin 1 (VNN1))
- Alternative Name
- VNN1/Vanin-1 (VNN1 Products)
- Synonyms
- HDLCQ8 Protein, Tiff66 Protein, V-1 Protein, hdlcq8 Protein, tiff66 Protein, vnn1.1 Protein, vanin-1 Protein, vanin 1 Protein, pantetheinase Protein, VNN1 Protein, Vnn1 Protein, vnn1 Protein, LOC100217969 Protein
- Background
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Background: Vanin-1 is a cell membrane protein which contains one CN hydrolase domain and belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 is also a member of the Vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. Vanin-1 is widely expressed with higher expression in spleen, kidney and blood and overexpressed in lesional psoriatic skin. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 Molecule was shown to be involved in the control of thymus reconstitution following sub-lethal irradiation.
Synonym: Pantetheinase, Pantetheine Hydrolase, Tiff66, Vascular Non-Inflammatory Molecule 1, Vanin-1, VNN1
- Molecular Weight
- 53.3 kDa
- UniProt
- O95497
- Pathways
- Negative Regulation of intrinsic apoptotic Signaling
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