Poliovirus Receptor Protein (PVR) (His tag)

Catalog No. ABIN7320997

This Recombinant Poliovirus Receptor protein is expressed in Human Cells.

Quick Overview for Poliovirus Receptor Protein (PVR) (His tag) (ABIN7320997)

Target: Poliovirus Receptor (PVR)

Protein Type: Recombinant

Origin: Rhesus Monkey

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Poliovirus Receptor protein is labelled with His tag.

Purpose: Recombinant Rhesus macaque CD155/PVR/NECL5 Protein (His Tag)

Sequence: Met 1-Asn 343

Characteristics: Recombinant Rhesus macaque NECL5 is produced by our Mammalian expression system and the target gene encoding Met 1-Asn 343 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Comment:

50-70 kDa

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Poliovirus Receptor (PVR)

Alternative Name: CD155/PVR/NECL5

Background:

Background: Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α, β, γ, and δ) with identical extracellular domains.

Synonym: Poliovirus Receptor, Nectin-Like Protein 5, NECL-5, CD155, PVR, PVS

Molecular Weight: 35.4 kDa

UniProt: Q0MSE6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome